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Gene fragments linked to brain development and autism
While the anti-vaccine movement enjoys the simple (and very wrong) answer to the cause of autism, there are people who want the actual truth. This drive had lead to a […]

Irimia, M., Weatheritt, R., Ellis, J., Parikshak, N., Gonatopoulos-Pournatzis, T., Babor, M., Quesnel-Vallières, M., Tapial, J., Raj, B., O’Hanlon, D. & Barrios-Rodiles, M. (2014). A Highly Conserved Program of Neuronal Microexons Is Misregulated in Autistic Brains, Cell, 159 (7) 1511-1523. DOI: 10.1016/j.cell.2014.11.035

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What’s the Answer? (FANTOM5 promoter atlas)
Biostars is a site for asking, answering and discussing bioinformatics questions and issues. We are members of the community and find it very useful. Often questions and answers arise at Biostars that are germane to our readers (end users of genomics resources). Every Thursday we will be highlighting one of those items or discussions here […]

Forrest A.R.R., Michael Rehli, J. Kenneth Baillie, Michiel J. L. de Hoon, Vanja Haberle, Timo Lassmann, Ivan V. Kulakovskiy, Marina Lizio, Masayoshi Itoh & Robin Andersson & (2014). A promoter-level mammalian expression atlas, Nature, 507 (7493) 462-470. DOI: http://dx.doi.org/10.1038/nature13182

Severin J., Jayson Harshbarger, Hideya Kawaji, Carsten O Daub, Yoshihide Hayashizaki, Nicolas Bertin & Alistair R R Forrest (2014). Interactive visualization and analysis of large-scale sequencing datasets using ZENBU, Nature Biotechnology, 32 (3) 217-219. DOI: http://dx.doi.org/10.1038/nbt.2840

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Happy Holidays: Gifts for the Deceased in Anglo-Saxon England
The holiday season is upon us, and that means that many of us are thinking about gifts. As I’ve been wrapping the presents I’ve bought for my family, I’ve been […]

King, J. (2004). Grave-Goods as Gifts in Early Saxon Burials (ca. AD 450-600), Journal of Social Archaeology, 4 (2) 214-238. DOI: 10.1177/1469605304041076

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Autistic traits in adults with epilepsy
"Increased autistic characteristics found in adults with epilepsy without an ASD [autism spectrum disorder] diagnosis suggest that epilepsy syndromes may incorporate behavioral aspects of autism in the absence of some of its core cognitive features."Contrariwise, if you think we're alive you ought to speak to us.That was the intriguing finding reported by Sally Ann Wakeford and colleagues [1] who examined test performance on the Autism Spectrum Quotient (AQ) and "systemizing […]

Wakeford S, Hinvest N, Ring H & Brosnan M (2014). Autistic characteristics in adults with epilepsy., Epilepsy & behavior : E&B, 41C 203-207. PMID: http://www.ncbi.nlm.nih.gov/pubmed/25461216

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Correcting Metabolic Abnormalities May Help Lessen Urinary Problems
Metabolic syndrome is linked with an increased frequency and severity of lower urinary tract symptoms, but weight loss surgery may lessen these symptoms. The findings, which come from two studies published in BJU International, indicate that urinary problems may be added to the list of issues that can improve with efforts that address altered metabolism. […] The post Correcting Metabolic Abnormalities May Help Lessen Urinary Problems appeared first on Wiley Asia Blog.

Pashootan, P., Ploussard, G., Cocaul, A., de Gouvello, A. & Desgrandchamps, F. (2014). Association between metabolic syndrome and severity of lower urinary tract symptoms (LUTS): an observational study in a 4666 European men cohort, BJU International, DOI: 10.1111/bju.12931

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Correcting Metabolic Abnormalities May Help Lessen Urinary Problems
Metabolic syndrome is linked with an increased frequency and severity of lower urinary tract symptoms, but weight loss surgery may lessen these symptoms. The findings, which come from two studies published in BJU International, indicate that urinary problems may be added to the list of issues that can improve with efforts that address altered metabolism. […] The post Correcting Metabolic Abnormalities May Help Lessen Urinary Problems appeared first on Wiley Asia Blog.

Pashootan, P., Ploussard, G., Cocaul, A., de Gouvello, A. & Desgrandchamps, F. (2014). Association between metabolic syndrome and severity of lower urinary tract symptoms (LUTS): an observational study in a 4666 European men cohort, BJU International, DOI: 10.1111/bju.12931

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Epigenetic changes and autism
Despite what you may think, the supposed “explosion” of children diagnosed with autism can directly attributed to better diagnosing techniques and — more importantly — the change of definition to […]

Gao, Z., Lee, P., Stafford, J., von Schimmelmann, M., Schaefer, A. & Reinberg, D. (2014). An AUTS2–Polycomb complex activates gene expression in the CNS, Nature, 516 (7531) 349-354. DOI: 10.1038/nature13921

Ntziachristos, P., Tsirigos, A., Welstead, G., Trimarchi, T., Bakogianni, S., Xu, L., Loizou, E., Holmfeldt, L., Strikoudis, A., King, B. & Mullenders, J. (2014). Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia, Nature, 514 (7523) 513-517. DOI: 10.1038/nature13605

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Google Translate not yet ready for medical communications
Image credits: frauczepluch.blogspot.com Communications is key in any relationship, particularly that between patients and doctors.  So what happens when the two parties don’t speak the same...

Patil S & Davies P (2014). Use of Google Translate in medical communication: evaluation of accuracy., BMJ (Clinical research ed.), 349 PMID: http://www.ncbi.nlm.nih.gov/pubmed/25512386

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Video Tip of the Week: yEd Graph Editor for visualizing pathways and networks
This week’s video tip of the week closes out a series that began last month. I started to explore one gene co-expression tool, which led me to another tool for visualization, and so on. This week’s tool is the final piece that you need to know about if you want to create the kind of […]

Wright D.W., Anton J. Enright & Tom C. Freeman (2014). Visualisation of BioPAX Networks using BioLayout Express3D, F1000Research, DOI: http://dx.doi.org/10.12688/f1000research.5499.1

Smoot M.E., J. Ruscheinski, P.-L. Wang & T. Ideker (2010). Cytoscape 2.8: new features for data integration and network visualization, Bioinformatics, 27 (3) 431-432. DOI: http://dx.doi.org/10.1093/bioinformatics/btq675

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Picking a New Dog is a Complex Choice
It’s not a case of ‘any puppy will do’ - the whole package counts.Photo: DragoNika / ShutterstockSurprisingly little is known about how people choose a new dog considering how popular they are. While it’s a personal choice, it has wider implications – humane societies would really like to know how to increase adoptions from shelters and decrease purchases from puppy mills. Could relocation programs, where dogs are brought in from out of town, be part of the […]

Garrison, L. & Weiss, E. (2014). What Do People Want? Factors People Consider When Acquiring Dogs, the Complexity of the Choices They Make, and Implications for Nonhuman Animal Relocation Programs, Journal of Applied Animal Welfare Science, 18 (1) 57-73. DOI: 10.1080/10888705.2014.943836

Mornement, K., Coleman, G., Toukhsati, S. & Bennett, P. (2012). What Do Current and Potential Australian Dog Owners Believe about Shelter Practices and Shelter Dogs?, Anthrozoos: A Multidisciplinary Journal of The Interactions of People & Animals, 25 (4) 457-473. DOI: 10.2752/175303712X13479798785850

Siettou, C., Fraser, I. & Fraser, R. (2014). Investigating Some of the Factors That Influence “Consumer” Choice When Adopting a Shelter Dog in the United Kingdom, Journal of Applied Animal Welfare Science, 17 (2) 136-147. DOI: 10.1080/10888705.2014.883924

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