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Experimental and comparative oncology: zebrafish, dogs, elephants
One of the exciting things about mathematical oncology is that thinking about cancer often forces me to leave my comfortable arm-chair and look at some actually data. No matter how much I advocate for the merits of heuristic modeling, when it comes to cancer, data-agnostic models take second stage to data-rich modeling. This close relationship […]

Gallaher, J. & Anderson, A.R. (2013). Evolution of intratumoral phenotypic heterogeneity: the role of trait inheritance., Interface Focus, 3 (4) 20130016. arXiv: http://arxiv.org/abs/1305.0524v1

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How to Look for Otters
In the first of a new series of posts about “How to Look for Mammals”, I take a look at one of our semi aquatic species, the Eurasian otter. The Eurasian otter is distributed across Europe and into Eurasia, but … Continue reading →

Reid N, Hayden B, Lundy MG, Pietravalle S, McDonald RA & Montgomery WI (2013). National Otter Survey of Ireland 2010/12, Irish Wildlife Manuals No. 76. National Parks and Wildlife Service, Department of Arts, Heritage and the Gaeltacht, Dublin, Ireland, Other:

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How to Look for Otters
In the first of a new series of posts about “How to Look for Mammals”, I take a look at one of our semi aquatic species, the Eurasian otter. The Eurasian otter is distributed across Europe and into Eurasia, but … Continue reading →

Reid N, Hayden B, Lundy MG, Pietravalle S, McDonald RA & Montgomery WI (2013). National Otter Survey of Ireland 2010/12, Irish Wildlife Manuals No. 76. National Parks and Wildlife Service, Department of Arts, Heritage and the Gaeltacht, Dublin, Ireland, Other:

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Is Stress Eating Away at You? No, Literally…
Ever wonder why, when people are too stressed, they are often grouchy, grumpy, nasty, distracted or forgetful? It may not be something you’ve done, in fact it turns out stress […]

van der Kooij, M., Fantin, M., Rejmak, E., Grosse, J., Zanoletti, O., Fournier, C., Ganguly, K., Kalita, K., Kaczmarek, L. & Sandi, C. & (2014). Role for MMP-9 in stress-induced downregulation of nectin-3 in hippocampal CA1 and associated behavioural alterations, Nature Communications, 5 4995. DOI: 10.1038/ncomms5995

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Pythons and the Land - The Bangladesh Python Project Part IV --Guest Post--
By Jon Hakim Make sure to start at Part I. “Snake call!  It's the python.  Are you up?  We got a call for the python.” The words were almost the same, but I woke up to see that Caesar's face held a grimace.  The call he feared had come.  Let's back up to the night before. In the last post I left you in a moment of triumph.  Kanai had led four of us right to our target species

Rahman, Shahriar Caesar & et al. (2013). Monsoon does matter: annual activity patterns in a snake assemblage from Bangladesh, The Herpetological Journal, 23 203-208.

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Anxiety and sensory over-responsivity linked to gut issues in autism
"The name's Lonnegan! Doyle Lonnegan!"Consider this micropost an extension of some previous discussions on this blog about how gastrointestinal (GI) issues present in cases of autism might show some connection to the presence of anxiety and sensory issues (see here). Today I'm discussing further research by Micah Mazurek and colleagues [1] which follows a previous publication by this author [2] on this topic.In the latest paper, Dr Mazurek and colleagues describe the course of abdominal pain in […]

Mazurek, M., Keefer, A., Shui, A. & Vasa, R. (2014). One-year course and predictors of abdominal pain in children with autism spectrum disorders: The role of anxiety and sensory over-responsivity, Research in Autism Spectrum Disorders, 8 (11) 1508-1515. DOI: 10.1016/j.rasd.2014.07.018

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Why are ethical standards higher in science than in business and media?
Facebook manipulates user content in the name of science? Scandalous! It manipulates user content in the name of profit? No worries! Want to run a Milgram study these days? Get bashed by your local ethics committee! Want to show it on TV? No worries. Why do projects which seek knowledge have higher ethical standards than […]

Kramer AD, Guillory JE & Hancock JT (2014). Experimental evidence of massive-scale emotional contagion through social networks., Proceedings of the National Academy of Sciences of the United States of America, 111 (24) 8788-90. PMID: http://www.ncbi.nlm.nih.gov/pubmed/24889601

Milgram, S. (1963). Behavioral Study of obedience, The Journal of Abnormal and Social Psychology, 67 (4) 371-378. Other:

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Biofilms: Using Bacteria for new Designer Nanomaterials
For most people biofilms conjure up images of slippery stones in a streambed and dirty drains. While there are plenty of “bad” biofilms around – they are even the same […]

Peter Q. Nguyen,, Zsofia Botyanszki,, Pei Kun R. Tay, & Neel S. Joshi (2014). Programmable biofilm-based materials from engineered curli nanofibres, Nature Communications, Other:

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(Transneuronal) Attack of the Mutant Huntingtin!
Huntington’s disease (HD) is an incredibly debilitating neurodegenerative disorder. Currently, there is no treatment that effectively reverses the progression of the disease or delays its onset. Huntington’s is a particularly difficult diagnosis because it is an autosomal dominant degenerative disease, meaning that any child of an affected parent has a 50% chance of inheriting the … Continue reading →

Pecho-Vrieseling E., Sascha Fuchs, Dorothee Bleckmann, Maria Soledad Esposito, Paolo Botta, Chris Goldstein, Mario Bernhard, Ivan Galimberti, Matthias Müller & Andreas Lüthi & (2014). Transneuronal propagation of mutant huntingtin contributes to non–cell autonomous pathology in neurons, Nature Neuroscience, 17 (8) 1064-1072. DOI: http://dx.doi.org/10.1038/nn.3761

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Antidepressants Modulate Memory in the Healthy Brain
The mechanism of antidepressant drug response is not well understood.One theory posits antidepressant effects are only seen in those with clinical depression leaving the healthy brain unchanged.In a previous post, I outlined a study demonstrating effects of antidepressants on brain connectivity measures in the healthy brain.A recent fMRI study extends our understanding of the potential mechanisms for antidepressant drugs.CT Cerqueira and colleagues from Brazil studied the effects of the […]

Cerqueira CT, Sato JR, de Almeida JR, Amaro E Jr, Leite CC, Gorenstein C, Gentil V & Busatto GF (2014). Healthy individuals treated with clomipramine: an fMRI study of brain activity during autobiographical recall of emotions., Translational psychiatry, 4 PMID: http://www.ncbi.nlm.nih.gov/pubmed/24984192

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